BAX Antibody [6A7] Cat. No.: 49-979

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human, Monkey, Mouse, Rat
IMMUNOGEN: BAX monoclonal antibody was raised against a synthetic peptide of BAX (Human).
TESTED APPLICATIONS: IHC, IP, WB
APPLICATIONS: IHC-P (10 - 12 ug/ml), IP

psi-iconProperties
PURIFICATION:Affinity Chromatography
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Store BAX antibody at -20 ˚C. Aliquot to avoid freeze/thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:BAX
ALTERNATE NAMES:BAX, BCL2-associated X protein, Bcl2-L-4, Apoptosis regulator BAX, Bcl-2-like protein 4, BCL2L4
ACCESSION NO.:Q07812
PROTEIN GI NO.:728945
GENE ID:581
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.

ANTIBODIES FOR RESEARCH USE ONLY.

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