Bax Antibody [2D2] Cat. No.: 99-622

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Bovine, Human, Monkey
IMMUNOGEN: Human Bax peptide (a.a. 3-16)
TESTED APPLICATIONS: Flow
APPLICATIONS: Bax Antibody [2D2] for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, purification, and neutralization assays.
SPECIFICITY: Bax

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG1
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:BAX
ALTERNATE NAMES:Apoptosis regulator BAX, BCL2 associated X protein
ACCESSION NO.:Q07812
GENE ID:581
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Bax is a 20-22 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. In murine thymocytes, it is expressed primarily as a cytoplasmic protein. Over-expression of Bax promotes apoptosis by formation of homodimers and through heterodimerization with Bcl-2, an inhibitor of apoptosis. The monoclonal antibody 2D2 reacts with an N-terminal epitope between amino acids 3-16 of human Bax. It can bind both soluble and detergent-altered forms of Bax as well as Bax-Bcl-2 and Bax-Bcl-xL heterodimers.

ANTIBODIES FOR RESEARCH USE ONLY.

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