Datasheet

BATF3 Antibody
CATALOG NUMBER: 7939

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:BATF3 body can be used for detection of BATF3 by Western blot at 0.5 μg/ml. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1210 - HEK293 Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 14 kDa

Observed: 17 kDa
SPECIFICITY:BATF3 antibody is human, mouse and rat reactive. BATF3 antibody is predicted to have no cross-reactivity to other BATF family members.
IMMUNOGEN:BATF3 antibody was raised against a 16 amino acid peptide near the amino terminus of human BATF3.

The immunogen is located within the first 50 amino acids of BATF3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:BATF3 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:BATF3 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:BATF3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Basic leucine zipper transcriptional factor ATF-like 3, SNFT, JDP1, JUNDM1
ACCESSION NO.:NP_061134
PROTEIN GI NO.:8924246
OFFICIAL SYMBOL:BATF3
GENE ID:55509

Background

BACKGROUND:BATF3, also known as SNFT, belongs to the basic leucine zipper transcriptional family and functions as a transcriptional repressor when heterodimerizing with Jun (1) and can repress the transcription of IL-2 and MMP-1 (1,2). BATF3 is required for the development of CD8alpha+ classical dendritic cells (DCs) and the related CD103+ DCs that cross-present antigens to CD8 T cells (3,4).
REFERENCES: 1) Iacobelli M, Wachsman W, and McGuire KL. Repression of IL-2 promoter activity by the novel basic leucine zipper p21SNFT protein. J. Immunol. 2000; 154:860-8.
2) Bower KE, Fritz JM, and McGuire KL. Transcriptional repression of MMP-1 by p21SNFT and reduced invasiveness of hepatocarcinoma cells. Oncogene 2004; 23:8805-14.
3) Hildner K, Edelson BT, Purtha WE, et al. BATF3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 2008; 322:1097-1100.
4) Edelson BT, Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J. Exp. Med. 2010; 207:823-36.

For Research Use Only