BAG2 Antibody Cat. No.: 29-709

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Dog, Human, Mouse, Rat, Zebrafish
IMMUNOGEN: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BAG2.
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: BAG2 antibody can be used for detection of BAG2 by ELISA at 1:1562500. BAG2 antibody can be used for detection of BAG2 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL:1) Cat. No. 1205 - Jurkat Cell Lysate
PREDICTED MOLECULAR WEIGHT: 23 kDa

psi-iconProperties
PURIFICATION:Antibody is purified by protein A chromatography method.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:For short periods of storage (days) store at 4˚C. For longer periods of storage, store BAG2 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:BAG2
ALTERNATE NAMES:BAG2, RP3-496N17.2, BAG-2, KIAA0576, MGC149462, dJ417I1.2
ACCESSION NO.:NP_004273
PROTEIN GI NO.:4757834
GENE ID:9532
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
REFERENCES:1) Arndt, V., (2005) Mol. Biol. Cell 16 (12), 5891-5900.

ANTIBODIES FOR RESEARCH USE ONLY.

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