BAFF Recombinant Protein Cat. No.: 90-301

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:CHO cells
SEQUENCE:The receptor-binding domain of human BAFF (aa 136-285) is fused at the N-terminus to the Fc portion of human IgG1.
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Rescues the production of mature follicular and marginal zone B cells. - in vitro: Addition of 1-100 ng/ml of Fc-BAFF induces B cell survival in a dose-dependent manner. - in vivo: Fc-BAFF treatment rescues mature B cell development in BAFF deficient mice. Mice are injected at day 0 with 100 ug Fc-BAFF i.v. and at day 14 with 50 ug Fc-BAFF i.p.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 100 μl sterile water.
CONCENTRATION:0.1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:BLyS, TALL-1, CD257, B Cell Activating Factor, TNFSF13B, Tumor Necrosis Factor Ligand Superfamily Member 13B
ACCESSION NO.:Q9Y275
PROTEIN GI NO.:5730097
OFFICIAL SYMBOL:TNFSF13B
GENE ID:10673
psi-iconBackground and References
BACKGROUND:BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers.

FOR RESEARCH USE ONLY.

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