BAFF-R Recombinant Protein Cat. No.: 90-237

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:The extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Inhibits BAFF activity. Detection of membrane-bound human and mouse BAFF in combination with PAb to human IgG1.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 50 μl sterile water.
CONCENTRATION:1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:TNFRSF 13C, Tumor Necrosis Factor Receptor Superfamily Member 13C, BR3, BlySR3, CD268, BAFF Receptor
ACCESSION NO.:Q96RJ3
PROTEIN GI NO.:15208475
OFFICIAL SYMBOL:TNFRSF13C
GENE ID:115650
psi-iconBackground and References
BACKGROUND:BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation . Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome , Rheumatoid Arthritis (RA) , Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) . BAFF is also increased levels in some lymphoid cancers.

FOR RESEARCH USE ONLY.

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