B7-H6 / NCR3LG1 Recombinant Protein Cat. No.: 11-451

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
SPECIES:Cynomolgus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Asp 25 - Asp 259
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.4 kDa. The protein migrates as 38-50 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:28.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:B7-H6,NCR3LG1,B7 Homolog 6
ACCESSION NO.:XP_005578557.1
OFFICIAL SYMBOL:NCR3LG1
GENE ID:102121659
psi-iconBackground and References
BACKGROUND:The B7 family of genes is essential in the regulation of the adaptive immune system. one of which is the recently discovered B7H6. Humans and rats have a single B7H6 gene; however, many B7H6 genes were detected in a single large cluster in the Xenopus genome. Chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable and potentially curative therapeutic efficacy against B-cell leukemia in clinical trials. In this study, B7H6, a ligand for the NK cell activating receptor NKp30, was targeted to create a CAR that targets multiple tumor types. B7H6 is expressed on various primary human tumors, including leukemia, lymphoma and gastrointestinal stromal tumors, but it is not constitutively expressed on normal tissues.
REFERENCES:1) Wu MR, et all., 2015, Gene Ther. 22(8):675-84.
2) Phillips M, et all., 2016, Biopolymers. 106(5):658-72.
3) Flajnik MF, et all., 2012 Immunogenetics. 64(8):571-90.

FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.