SPECIES: | Human |
SOURCE SPECIES: | Human Cells |
SEQUENCE: | Leu29-Thr461 |
FUSION TAG: | C-6 His tag |
TESTED APPLICATIONS: | |
APPLICATIONS: | This recombinant protein can be used for biological assays. For research use only. |
PURITY: | Greater than 95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. |
PREDICTED MOLECULAR WEIGHT: | 47.3 kD |
PHYSICAL STATE: | Lyophilized |
BUFFER: | Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. |
STORAGE CONDITIONS: | Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months. |
ALTERNATE NAMES: | CD276, B7H34Ig-B7-H3, B7-H3, B7 homolog 3, CD276 antigen, CD276 molecule, Costimulatory molecule |
ACCESSION NO.: | Q5ZPR3 |
OFFICIAL SYMBOL: | CD276 |
GENE ID: | 80381 |
BACKGROUND: | CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20–27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration. |
FOR RESEARCH USE ONLY.
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