B7-H3 / CD276 Recombinant Protein Cat. No.: 11-279

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psi-iconSpecifications
SPECIES:Cynomolgus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Leu 29 - Glu 465
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.0 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:49.0 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:B7-H3,CD276,B7 homolog 3
ACCESSION NO.:XP_015308534.1
OFFICIAL SYMBOL:CD276
GENE ID:102131295
psi-iconBackground and References
BACKGROUND:B7 homolog 3 (B7-H3), a member of the immunoglobulin superfamily, is also known CD276, which contains two Ig-like C2-type (immunoglobulin-like) domains and two Ig-like V-type (immunoglobulin-like) domains. B7-H3 may participate in the regulation of T-cell-mediated immune response. B7-H3 also plays a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. Furthermore, B7-H3 is involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy.
REFERENCES:1) Chapoval A.I., et al., 2001, Nat. Immunol. 2:269-274.
2) Castriconi R., et al., 2004, Proc. Natl. Acad. Sci. U.S.A. 101:12640-12645.
3) Wang L., et al., 2005, Eur. J. Immunol. 35:428-438.

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