Autophagy protein 5 Recombinant Protein Cat. No.: 92-187

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:Met1-Asp275
FUSION TAG:Tag Free
TESTED APPLICATIONS:
APPLICATIONS:This recombinant protein can be used for biological assays. For research use only.
psi-iconProperties
PURITY:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
PREDICTED MOLECULAR WEIGHT:32.4 kD
PHYSICAL STATE:Liquid
BUFFER:Supplied as a 0.2 um filtered solution of 20mM Tris,0.2M NaCl,1mM DTT,40%glycerol, pH 8.0 . It is not recommended to reconstitute to a concentration less than 100 ug/ml.
STORAGE CONDITIONS:Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Autophagy protein 5, APG5-like, Apoptosis-specific protein, APG5L, ASP, ATG5
ACCESSION NO.:Q9H1Y0
PROTEIN GI NO.:530379522
OFFICIAL SYMBOL:ATG5
GENE ID:9474
psi-iconBackground and References
BACKGROUND:ATG5 is an E2 ubiquitin ligase which is necessary for autophagy. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity, dramatically highly expressed in apoptotic cells. It is activated by ATG7, conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate complex detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 plays an important role in the apoptotic process, possibly within the modified cytoskeleton.

FOR RESEARCH USE ONLY.

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