ATG4B Antibody Cat. No.: 33-063

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: A recombinant protein fragment from the C-terminal region of ATG4B was used as the immunogen for this antibody.
TESTED APPLICATIONS: WB
APPLICATIONS: Western blot: 4-8 ug/ml

Provided assay concentrations are suggestions only, ATG4B antibody titration may be required for optimal results.

psi-iconProperties
PURIFICATION:Protein A affinity chromatography
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.1 mg/ml BSA and 0.05% sodium azide
CONCENTRATION:0.5 mg/mL
STORAGE CONDITIONS:Aliquot and Store at -20˚C. Avoid freez-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:ATG4B
ALTERNATE NAMES:Autophagy related 4B cysteine peptidase, APG4B, APG4-B, AUTL1
GENE ID:23192
USER NOTE:Optimal dilutions for each application to be determined by the researcher
psi-iconBackground and References
BACKGROUND:Autophagy is the cellular mechanism of degradation and turnover of unnecessary or dysfunctional cellular components. The unneeded components are engulfed in vesicles called autophagosomes, where they are broken down and recycled. The ‘autophagy-related gene’ ATG4B is a regulator of autophagasome maturation. The microtubule-associated protein LC3-I is lipidated (called LC3-II in its lipidated state) and recruited to the autophagosomal membrane where it is of vital importance in the maturation of autophagosomes. ATG4B regulates LC3-II availability by modulating LC3-I lipidation.

ANTIBODIES FOR RESEARCH USE ONLY.

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