Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Human |
| IMMUNOGEN: |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2). |
| TESTED APPLICATIONS: |
IF |
| APPLICATIONS: |
IF: ,1:50 - 1:200 |
Properties
| PURIFICATION: | Affinity purification |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| STORAGE CONDITIONS: | Store at -20˚C. Avoid freeze / thaw cycles. |
Additional Info
| OFFICIAL SYMBOL: | ASIP |
| ALTERNATE NAMES: | AGSW, AGTI, AGTIL, ASP, SHEP9, agouti-signaling protein, agouti signaling protein, nonagouti homolog, agouti switch protein, nonagouti homolog |
| GENE ID: | 434 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. |
ANTIBODIES FOR RESEARCH USE ONLY.
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