| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | ARHGAP39 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human ARHGAP39. The immunogen is located within amino acids 880 - 930 of ARHGAP39. |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | ARHGAP39 antibody can be used for detection of ARHGAP39 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. |
| SPECIFICITY: | ARHGAP39 antibody is predicted to not cross-react with other RhoGAP protein family members. |
| POSITIVE CONTROL: | 1) Cat. No. 1288 - A20 Cell Lysate |
Specifications| PURIFICATION: | ARHGAP39 Antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | ARHGAP39 Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | ARHGAP39 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| OFFICIAL SYMBOL: | ARHGAP39 |
| ALTERNATE NAMES: | ARHGAP39 Antibody: CrGAP, Vilse, KIAA1688, Rho GTPase-activating protein 39 |
| ACCESSION NO.: | NP_079527 |
| PROTEIN GI NO.: | 58331179 |
| GENE ID: | 80728 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | ARHGAP39 Antibody: Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins. ARHGAP39 (Rho GTPase activating protein 39) is a 1, 083 amino acid nuclear protein that contains one MyTH4 domain, one Rho GAP domain and two WW domains. It is encoded by a gene located on human chromosome 8, which is associated with a variety of diseases and malignancies. ARHGAP39 regulates robo signaling and plays important roles in axon guidance. |
| REFERENCES: | 1) Takai Y, Sasaki T, and Matozaki T. Small GTP-binding proteins. Physiol. Rev. 2001; 81:153-208. | 2) Hu H, Li M, Labrador JP, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc. Natl. Acad. Sci. USA 2005; 102:4613-8 | 3) Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature 2006; 439:331-5 | 4) Lundström A, Gallio M, Englund C, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004; 18:2161-71. |
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