APRIL Recombinant Protein Cat. No.: 40-302

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:High-5 Insect cells
SEQUENCE:AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
BIOLOGICAL ACTIVITY: Determined by its ability to induce NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.
psi-iconProperties
PURITY:Greater than 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:Lyophilized
STORAGE CONDITIONS:The lyophilized APRIL recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted APRIL is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing APRIL recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:APRIL, CD256, TALL2, ZTNF2, TALL-2, TRDL-1, UNQ383/PRO715, APRIL, Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand
ACCESSION NO.:NP_001185551.1
PROTEIN GI NO.:310750385
OFFICIAL SYMBOL:TNFSF13
GENE ID:8741
psi-iconBackground and References
BACKGROUND:APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, compete for two receptors, TACI and BCMA. ARPIL has the ability to stimulate proliferation of various tumor cell lines including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF like receptor binding of the APRIL precursor. Recombinant human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.

FOR RESEARCH USE ONLY.

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