APPBP2 Antibody Cat. No.: 7563

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: APPBP2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human APPBP2.

The immunogen is located within the last 50 amino acids of APPBP2.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 64 kDa

Observed: 57 kDa

psi-iconProperties
PURIFICATION:APPBP2 antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:APPBP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:APPBP2
ALTERNATE NAMES:APPBP2 Antibody: PAT1, APP-BP2, HS.84084, KIAA0228, PAT1, Amyloid protein-binding protein 2, Amyloid beta precursor protein-binding protein 2
ACCESSION NO.:NP_006371
PROTEIN GI NO.:18104962
GENE ID:10513
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).
REFERENCES:1) Zheng P, Eastman J, Vande Pol S, et al. PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein. Proc. Natl. Acad. Sci. USA 1994; 95:14745-50.
2) Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annu. Rev. Cell Biol. 1994; 10:373-403.
3) Li J, Yang Y, Peng Y, et al. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nat. Genet. 2002; 31:133-4.

ANTIBODIES FOR RESEARCH USE ONLY.

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