ApoA5 Antibody Cat. No.: 6271

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Chicken, Human
IMMUNOGEN: ApoA5 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of chicken ApoA5.

The immunogen is located within the last 50 amino acids of ApoA5.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: ApoA5 antibody can be used for detection of ApoA5 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate

psi-iconProperties
PURIFICATION:ApoA5 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:ApoA5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ApoA5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:APOA5
ALTERNATE NAMES:ApoA5 Antibody:
ACCESSION NO.:XP_417939
PROTEIN GI NO.:118101989
GENE ID:419802
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:ApoA5 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but several evidences from vitro studies indicate that this apolipoprotein involves in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.
REFERENCES:1) Van der Vliet HN, Sammels MG, Leegwater AC, et al. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. J. Biol. Chem. 2001; 276: 44512-20
2) Vu-Dac N, Gervois P, Jakel H, Nowak M, et al. Apolipoprotein A5, a crucial determinant of plasma triglyceride levels, is highly responsive to peroxisome proliferator-activated receptor alpha activators. J. Biol.Chem. 2003; 278:17982-5
3) Nilsson SK, Christensen S, Raarup MK, et al. Endocytosis of apolipoprotein AV by members of the low density lipoprotein receptor and the Vps10p domain receptor families" J. Biol. Chem. 2008; 283: 25920-7.

ANTIBODIES FOR RESEARCH USE ONLY.

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