ApoA1 Antibody Cat. No.: 6265

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Chicken, Human
IMMUNOGEN: ApoA1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ApoA1.

The immunogen is located within the last 50 amino acids of ApoA1.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: ApoA1 antibody can be used for detection of ApoA1 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in chicken samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Chicken Liver Lysate

psi-iconProperties
PURIFICATION:ApoA1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:ApoA1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ApoA1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:APOA1
ALTERNATE NAMES:ApoA1 Antibody: Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
ACCESSION NO.:P02647
PROTEIN GI NO.:113992
GENE ID:335
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:ApoA1 Antibody: Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) in plasma, which is correlated with cardiovascular disease. ApoA1 is synthesized in the liver and small intestine and promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT), the enzyme responsible for the formation of most plasma cholesteryl esters. Defects in ApoA1 are associated with HDL deficiency, Tangier disease, and systemic non-neuropathic amyloidosis.
REFERENCES:1) Zhu X, Wu G, Zeng W, et al. Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties. J. Lipid Res. 2005; 46:1303-11
2) Sorci-Thomas MG, Prack MM, Dashti N, et al. Differential effects of dietary fat on the tissue-specific expression of the apolipoprotein A-I gene: relationship to plasma concentration of high density lipoproteins. J. Lipid Res. 1989; 30:1397-403
3) Lai C-Q, Parnell LD, and Ordovas JM. The APOA1 /C3/A4/A5 gene cluster, lipid metabolism and cardiovascular disease risk. Curr. Opin. Lipid. 2005; 16:153-66

ANTIBODIES FOR RESEARCH USE ONLY.

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