Angiopoietin-2 Recombinant Protein Cat. No.: 90-295

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a DDDDK-tag.
FUSION TAG:DDDDK Tag
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: N/A
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS with trehalose and Brij35. Reconstitute with 100 μl sterile water.
CONCENTRATION:0.1 mg /ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:Ang-2, Ang2, Angpt2
ACCESSION NO.:O15123
PROTEIN GI NO.:4557315
OFFICIAL SYMBOL:ANGPT2
GENE ID:285
psi-iconBackground and References
BACKGROUND:Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

FOR RESEARCH USE ONLY.

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