| SPECIES: | Human, Mouse |
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a DDDDK-tag. |
| FUSION TAG: | DDDDK Tag |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | N/A |
Specifications| PURITY: | >95% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza). |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Contains PBS with trehalose and Brij35. Reconstitute with 100 μl sterile water. |
| CONCENTRATION: | 0.1 mg /ml after reconstitution. |
| STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at -20˚C. |
| ALTERNATE NAMES: | Ang-2, Ang2, Angpt2 |
| ACCESSION NO.: | O15123 |
| PROTEIN GI NO.: | 4557315 |
| OFFICIAL SYMBOL: | ANGPT2 |
| GENE ID: | 285 |
| BACKGROUND: | Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. |
FOR RESEARCH USE ONLY.
For additional information, visit ProSci's Terms & Conditions Page.
