Amyloid-Beta 3 Antibody Cat. No.: 39-850

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Bovine, Human, Non-human Primate, Sheep
IMMUNOGEN: A synthetic peptide corresponding to the N-terminus 3-pyro E start point.
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: ELISA , Western (immuno) blotting (in testing), Immunostaining (in testing)

psi-iconProperties
PURIFICATION:Affinity Purified
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid

psi-iconAdditional Info
OFFICIAL SYMBOL:APP
ALTERNATE NAMES:Amyloid-Beta 3-pyr E, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4
ACCESSION NO.:P05067
PROTEIN GI NO.:112927
GENE ID:351
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Pyro-glutamic acid truncated amyloid beta 3-40/42 may have a greater propensity to aggregate under physiological conditions. In addition, this pyro E modification has been implicated as the molecular species responsible for seeding larger oligomers of amyloid-β. Pyro-glutamic acid truncated amyloid beta 3-40/42’s exact involvement in the pathophysiology of Alzheimer’s disease has not been established.
REFERENCES:1) Schilling S, Lauber T, Schaupp M, Manhart S, Scheel E, Bohm G, Demuth HU. On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). Biochemistry. 2006 Oct 17;45(41):12393-9
2) He W, Barrow CJ. The A beta 3-pyroglutamyl and 11-pyroglutamyl peptides found in senile plaque have greater beta-sheet forming and aggregation propensities in vitro than full-length A beta. Biochemistry. 1999 Aug 17;38(33):10871-7
3) Alzheimer research forum review see http://www.alzforum.org/new/detailprint.asp?id=1577
4) Youssef I, Florent-Béchard S, Malaplate-Armand C, Koziel V, Bihain B, Olivier JL, Leininger-Muller B, Kriem B, Oster T, Pillot T., N-truncated amyloid-beta oligomers induce learning impairment and neuronal apoptosis. Neurobiology of Aging 29 (2008) 1319-1333

ANTIBODIES FOR RESEARCH USE ONLY.

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