| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human |
| IMMUNOGEN: | This AMPK alpha(PRKAA1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from human AMPK alpha(PRKAA1). |
| TESTED APPLICATIONS: | IHC-P, WB |
| APPLICATIONS: | For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50 |
| PREDICTED MOLECULAR WEIGHT: | 64 kDa |
Specifications| PURIFICATION: | This antibody is purified through a protein A column, followed by peptide affinity purification. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | Rabbit Ig |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Supplied in PBS with 0.09% (W/V) sodium azide. |
| CONCENTRATION: | 0.31 mg/ml |
| STORAGE CONDITIONS: | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| OFFICIAL SYMBOL: | PRKAA1 |
| ALTERNATE NAMES: | 5'-AMP-activated protein kinase catalytic subunit alpha-1, AMPK subunit alpha-1, Acetyl-CoA carboxylase kinase, ACACA kinase, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, Tau-protein kinase PRKAA1, PRKAA1, AMPK1 |
| ACCESSION NO.: | Q13131 |
| PROTEIN GI NO.: | 254763436 |
| GENE ID: | 5562 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. |
| REFERENCES: | 1) Pang,T., J. Biol. Chem. 282 (1), 495-506 (2007) | 2) Crawford,R.M., Cell. Signal. 18 (10), 1595-1603 (2006) | 3) Crawford,R.M., Mol. Cell. Biol. 26 (15), 5921-5931 (2006) |
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