Alzheimers Disease B-Amyloid Protein Detection Set Cat. No.: PSI-1812

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psi-iconSpecifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:IHC, WB
APPLICATIONS:These polyclonal antibodies can be used for detection of APP, BACE and BACE2 by immunoblot at 1 - 5 μgg/mL. APP and BACE antibodies can detect their respective proteins via immunohistochemistry at 2 - 10 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
SPECIFICITY:Both APP antibodies will react with the C99 fragment of APP.
IMMUNOGEN:Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.

psi-iconSet Contents

Catalog Number 2136Catalog number 2136 — APP Antibody
Catalog Number 2133Catalog number 2133 — APP Antibody
Catalog Number 2253Catalog number 2253 — BACE Antibody
Catalog Number 2247Catalog number 2247 — BACE2 Antibody

psi-iconProperties

PHYSICAL STATE:Liquid
BUFFER:PBS containing 0.02% sodium azide.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:Stable at 4˚C for three months, store at -20˚C for up to one year.

psi-iconAdditional Info

USER NOTE:Optimal dilutions for each application to be determined by the researcher.

psi-iconBackground

BACKGROUND:Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The βamyloid protein precursor (APP) is cleaved by one of two βsecretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for βsecretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer’s disease patients’ brains. BACE was identified by several groups independently and designated β-site APP cleaving enzyme (BACE) . BACE is a transmembrane aspartic protease and co-localizes with APP. BACE2 also cleaves APP at β-site and at a different site within Aβ. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.

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DETECTION-SETS FOR RESEARCH USE ONLY.

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