ALDH4A1 Antibody Cat. No.: 30-100

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Dog, Human, Mouse, Zebrafish
IMMUNOGEN: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ALDH4A1.
TESTED APPLICATIONS: ELISA, IHC, WB
APPLICATIONS: ALDH4A1 antibody can be used for detection of ALDH4A1 by ELISA at 1:312500. ALDH4A1 antibody can be used for detection of ALDH4A1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL:1) Cat. No. XBL-10409 - Fetal Liver Tissue Lysate
PREDICTED MOLECULAR WEIGHT: 62 kDa, 62 kDa

psi-iconProperties
PURIFICATION:Antibody is purified by protein A chromatography method.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:For short periods of storage (days) store at 4˚C. For longer periods of storage, store ALDH4A1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:ALDH4A1
ALTERNATE NAMES:ALDH4A1, ALDH4, P5CD, P5CDh, P5CDhL, P5CDhS
ACCESSION NO.:NP_003739
PROTEIN GI NO.:25777734
GENE ID:8659
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Two transcript variants encoding the same protein have been identified for this gene.
REFERENCES:1) Yoon, K.A., (2004) J. Hum. Genet. 49 (3), 134-140.

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