AKT1 Antibody Cat. No.: XW-7019

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psi-iconSpecifications
HOST SPECIES:Chicken
SPECIES REACTIVITY: Bovine, Xenopus
IMMUNOGEN: 2-200
TESTED APPLICATIONS: WB
APPLICATIONS: AKT antibody can be used for the detection of AKT by Western blot, may also work for IHC and ICC.
PREDICTED MOLECULAR WEIGHT: 55.7 kDa (calculated)

psi-iconProperties
PURIFICATION:Antigen affinity-purified
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Phosphate-Buffered Saline. No preservatives added.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:AKT1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:AKT1
ALTERNATE NAMES:PKB, RACProtein kinase B, PKB, AKT, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA,
ACCESSION NO.:NP_005154.1
PROTEIN GI NO.:4885061
GENE ID:207
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Serine/threonine protein kinase; Murine thymoma viral (v-akt) oncogene homolog-1. AKT1 is a serine-threonine protein kinase. It is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
REFERENCES:1) Brunet,A., Bonni,A., Zigmond,M. J., Lin,M. Z., Juo,P., Hu,L. S., Anderson,M. J., Arden,K. C., Blenis,J. and Greenberg,M. E. TITLE Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor JOURNAL Cell 96 (6), 857-868 (1999).

ANTIBODIES FOR RESEARCH USE ONLY.

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