Specifications
| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: |
Human, Mouse, Rat |
| IMMUNOGEN: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_003730.4). |
| TESTED APPLICATIONS: |
IP, WB |
| APPLICATIONS: |
WB: ,1:500 - 1:2000
IP: ,1:50 - 1:100 |
| POSITIVE CONTROL: | 1) U-87MG |
| | 2) 293T |
| | 3) LO2 |
| | 4) A-549 |
| | 5) DU145 |
| | 6) Mouse kidney |
| PREDICTED MOLECULAR WEIGHT: |
Observed: 37kDa |
Properties
| PURIFICATION: | Affinity purification |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| STORAGE CONDITIONS: | Store at -20˚C. Avoid freeze / thaw cycles. |
Additional Info
| OFFICIAL SYMBOL: | AKR1C3 |
| ALTERNATE NAMES: | AKR1C3, DD3, HAKRB, HAKRe, HA1753, HSD17B5, hluPGFS, KIAA0119, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), prostaglandin F synthase, dihydrodiol dehydrogenase 3, chlordecone reductase homolog, hydroxysteroid (17-beta) dehydrogenase 5, type IIb 3-alpha hydroxysteroid dehydrogenase, trans-1, 2-dihydrobenzene-1, 2-diol dehydrogenase, DDH1, PGFS |
| GENE ID: | 8644 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
Background and References
| BACKGROUND: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. |
ANTIBODIES FOR RESEARCH USE ONLY.
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