AIMP1 Recombinant Protein Cat. No.: 96-820

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:Ala 2 - Lys 312
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:35.2 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:AIMP1,EMAP2,EMAPII,HLD3,SCYE1,p43,EMAP-2,EMAP-II,AIMP-1
ACCESSION NO.:AAH14051
OFFICIAL SYMBOL:AIMP1
GENE ID:9255
psi-iconBackground and References
BACKGROUND:Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) is also known as multisynthase complex auxiliary component p43 and endothelial monocyte-activating polypeptide II (EMAP-II). AIMP1 is a cytokine that may be induced by apoptosis and is also released from professional antigen-presenting cells such as dendritic cells. The release of AIMP1 renders the tumor-associated vasculature sensitive to tumor necrosis factor. Furthermore, AIMP1 binds tRNA and stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. This protein possesses inflammatory cytokine activity. Also, AIMP1 negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation.
REFERENCES:1) Barnett G., et al., 2000, Cancer Res. 60:2850-2857.
2) Park S.G., et al., 1999, J. Biol. Chem. 274:16673-16676.
3) Tandle A.T., et al., 2009, Exp. Cell Res. 315:1850-1859.

FOR RESEARCH USE ONLY.

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