AIFM1 Antibody Cat. No.: 49-526

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Bat, Bovine, Dog, Gibbon, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
IMMUNOGEN: AIFM1 antibody was raised against amino acids 593-606 of AIFM1 (Human).
TESTED APPLICATIONS: IHC, WB
APPLICATIONS: AImmunofluorescenceM1 antibody can be used in ELISA, Western Blot, and immunohistochemistry starting at 5 μg/mL.

psi-iconProperties
PURIFICATION:Purified
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS, 0.02% sodium azide.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:AIFM1
ALTERNATE NAMES:AIFM1, AIF, COXPD6, PDCD8, Programmed cell death 8
ACCESSION NO.:O95831
PROTEIN GI NO.:13431764
GENE ID:9131
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins. A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and large scale DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection and apoptosis stimuli. AIF is highly conserved between human and mouse and widely expressed.

ANTIBODIES FOR RESEARCH USE ONLY.

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