AFX (phospho Ser197) Antibody Cat. No.: 79-168

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: AFX (Phospho-Ser197) antibody was raised against a peptide sequence around phosphorylation site of serine 197 (A-A-S (p) -M-D) derived from Human AFX.
TESTED APPLICATIONS: IF, IHC, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level of AFX only when phosphorylated at serine 197.
PREDICTED MOLECULAR WEIGHT: 65 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:FOXO4
ALTERNATE NAMES:AFX, AFX1, MLLT7, EIF2A, AFX, FOXO4, Afxh
ACCESSION NO.:NP_001164402.1
PROTEIN GI NO.:283436083
GENE ID:4303
psi-iconBackground and References
BACKGROUND:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
REFERENCES:1) Di Maira G, et al. (2005) Cell Death Differ; 12 (6): 668-77. Essers MA, et al. EMBO J 2004 Nov. 11. Brownawell AM, (2001) Mol Cell Biol; 21 (10): 3534-46. Kops GJ, et al. (1999) Nature; 398 (6728): 630-4.

ANTIBODIES FOR RESEARCH USE ONLY.

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