| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | Adiponectin antibody was raised against a peptide sequence around aa.235~239 (T-G-F-L-L) derived from Human Adiponectin. |
| TESTED APPLICATIONS: | WB |
| APPLICATIONS: | Western Blot: 1:500~1:1000 |
| SPECIFICITY: | This antibody detects endogenous level of total Adiponectin protein. |
| PREDICTED MOLECULAR WEIGHT: | 27 kDa |
Specifications| PURIFICATION: | Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | Store antibody at -20˚C for up to one year. |
| OFFICIAL SYMBOL: | ADIPOQ |
| ALTERNATE NAMES: | ACDC, ADPN, APM1, APM-1, GBP28, ACRP30, ADIPQTL1, ACDC |
| ACCESSION NO.: | NP_001171271.1 |
| PROTEIN GI NO.: | 295317372 |
| GENE ID: | 9370 |
| BACKGROUND: | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-κ-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. |
| REFERENCES: | 1) Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., Mori Y., Ide T., Murakami K., Yoda M. Kadowaki T. Nat. Med. 7:941-946 (2001) Richards A. A., Stephens T., Charlton H. K., Jones A., Macdonald G. A., Prins J. B., Whitehead J. P. Mol. Endocrinol. 20:1673-1687 (2006) |
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