Adipokines: Adiponectin and CTRPs 1-7 Detection Set Cat. No.: PSI-1804

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:IF, IHC, WB
APPLICATIONS:These polyclonal antibodies can be used for detection of the indicated adipokines by Western blot at 1 μg/mL to 2 μg/mL , Immunohistochemistry, and Immunoflourescence.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
psi-iconSet Contents
Catalog Number 3551Catalog number 3551 — Adiponectin Antibody
Catalog Number 3557Catalog number 3557 — CTRP1 Antibody
Catalog Number 3561Catalog number 3561 — CTRP2 Antibody
Catalog Number 3565Catalog number 3565 — CTRP3 Antibody
Catalog Number 3567Catalog number 3567 — CTRP4 Antibody
Catalog Number 3571Catalog number 3571 — CTRP5 Antibody
Catalog Number 3575Catalog number 3575 — CTRP6 Antibody
Catalog Number 3579Catalog number 3579 — CTRP7 Antibody
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:PBS containing 0.02% sodium azide.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:Stable at 4˚C for three months, store at -20˚C for up to one year.
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-Α-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. Adiponectin is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene.

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