ADD1 (phospho Ser726) Antibody Cat. No.: 79-189

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: ADD1 (Phospho-Ser726) antibody was raised against a peptide sequence around phosphorylation site of serine 726 (T-P-S (p) -F-L) derived from Human ADD1.
TESTED APPLICATIONS: IF, IHC, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level of ADD1only when phosphorylated at serine 726.
PREDICTED MOLECULAR WEIGHT: 130 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:ADD1
ALTERNATE NAMES:ADDA, FAK, FAK1, ADDA, Erythrocyte adducin alpha subunit
ACCESSION NO.:NP_001110.2
PROTEIN GI NO.:29826319
GENE ID:118
psi-iconBackground and References
BACKGROUND:Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described.
REFERENCES:1) Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102 (35): 12407-12Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332 (2): 347-51Barkalow KL, et al. J Cell Biol 2003 May 12; 161 (3): 557-70

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