| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | ADD1 (Ab-726) antibody was raised against a peptide sequence around aa.724~728 (T-P-S-F-L) derived from Human ADD1. |
| TESTED APPLICATIONS: | IF, IHC, WB |
| APPLICATIONS: | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200 |
| SPECIFICITY: | This antibody detects endogenous level of total ADD1 protein. |
| PREDICTED MOLECULAR WEIGHT: | 130 kDa |
Specifications| PURIFICATION: | Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| CLONALITY: | Polyclonal |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | Store antibody at -20˚C for up to one year. |
| OFFICIAL SYMBOL: | ADD1 |
| ALTERNATE NAMES: | ADDA, ERBB, ERBB1, HER1, ADDA, Erythrocyte adducin alpha subunit |
| ACCESSION NO.: | NP_001110.2 |
| PROTEIN GI NO.: | 29826319 |
| GENE ID: | 118 |
| BACKGROUND: | Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. |
| REFERENCES: | 1) Pariser H, et al. Proc Natl Acad Sci USA 2005 Aug 30; 102 (35): 12407-12Tamaru S, et al. Biochem Biophys Res Commun 2005 Jul 01; 332 (2): 347-51Barkalow KL, et al. J Cell Biol 2003 May 12; 161 (3): 557-70 |
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