Specifications
Properties
Additional Info
Background
Specifications
| SPECIES REACTIVITY: | Human, Mouse, Rat |
|---|---|
| TESTED APPLICATIONS: | ELISA, IF, IHC-P, WB |
| APPLICATIONS: | ADAMTSL5 antibody can be used for detection of ADAMTSL5 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| POSITIVE CONTROL: | 1) Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate |
| IMMUNOGEN: | ADAMTSL5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ADAMTSL5. The immunogen is located within the last 50 amino acids of ADAMTSL5. |
| HOST SPECIES: | Chicken |
Properties
| PURIFICATION: | ADAMTSL5 Antibody is affinity chromatography purified via peptide column. |
|---|---|
| PHYSICAL STATE: | Liquid |
| BUFFER: | ADAMTSL5 Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | ADAMTSL5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgY |
| CONJUGATE: | Unconjugated |
Additional Info
| ALTERNATE NAMES: | ADAMTSL5 Antibody: THSD6, THSD6, ADAMTS-like protein 5, Thrombospondin type-1 domain-containing protein 6, ADAMTSL-5 |
|---|---|
| ACCESSION NO.: | NP_998769 |
| PROTEIN GI NO.: | 226442878 |
| OFFICIAL SYMBOL: | ADAMTSL5 |
| GENE ID: | 339366 |
Background
| BACKGROUND: | ADAMTSL5 Antibody: ADAMTSL5 belongs to a large superfamily containing 20 ADAMTS proteases and at least eight ADAMTS-like proteins. ADAMTS proteases are secreted enzymes with a conserved organization that includes a metalloprotease domain and an ancillary domain containing one or more thrombospondin type 1 repeats (TSR). The ADAMTS-like subfamily comprises proteins homologous to the ADAMTS ancillary domains but lacking the protease domain and hence lacking catalytic activity. The exact role of ADAMTSL5 is currently unknown, but other ADAMTS-like proteins appear to have regulatory roles in the extracellular matrix. |
|---|---|
| REFERENCES: | 1) Jones GC and Riley GP. ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis. Arth. Res. and Ther.2005; 7:160-9. | 2) Apte SS. A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms. J. Biol. Chem.2009; 284:31493-7. |
For Research Use Only
