ADAMTS4 Antibody Cat. No.: 48-124

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Dog, Gibbon, Horse, Human, Orangutan
IMMUNOGEN: ADAMTS4 antibody was raised against a peptide located in the C-Terminal domain of ADAMTS4 (Human).
TESTED APPLICATIONS: IHC
APPLICATIONS: ADAMTS4 antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.
SPECIFICITY: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

psi-iconProperties
PURIFICATION:Immunoaffinity Chromatography
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS, 0.1% sodium azide.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Store ADAMTS4 antibody at 4 ˚C for short term applications. For long term storage, aliquot and -20 ˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:ADAMTS4
ALTERNATE NAMES:ADAMTS4, ADAMTS-2, ADAMTS-4, ADAM-TS 4, ADAM-TS4, ADMP-1, Aggrecanase-1, KIAA0688
ACCESSION NO.:O75173
PROTEIN GI NO.:317373445
GENE ID:9507
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease.

ANTIBODIES FOR RESEARCH USE ONLY.

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