ADAM17 Recombinant Protein Cat. No.: 96-968

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:Pro 18 - Asp 563
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:63.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:50 mM MES, 150 mM NaCl, pH6.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:ADAM17,TACE,CD156b
ACCESSION NO.:Q9Z0F8
OFFICIAL SYMBOL:ADAM17
GENE ID:11491
psi-iconBackground and References
BACKGROUND:Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
REFERENCES:1) Black R., et al., 1997, Nature 385 (6618): 729–33
2) Moss M., et al., 1997, Nature 385 (6618): 733–6
3) Schroeter E., et al., 1998, Nature 393 (6683): 382–6.

FOR RESEARCH USE ONLY.

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