ADA Antibody Cat. No.: 26-611

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psi-iconSpecifications

HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ADA.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: ADA antibody can be used for detection of ADA by ELISA at 1:62500. ADA antibody can be used for detection of ADA by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL:1) Cat. No. XBL-10413 - Fetal Skeletal Muscle Tissue Lysate
PREDICTED MOLECULAR WEIGHT: 41 kDa

psi-iconProperties

PURIFICATION:Antibody is purified by peptide affinity chromatography method.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:For short periods of storage (days) store at 4˚C. For longer periods of storage, store ADA antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

psi-iconAdditional Info

OFFICIAL SYMBOL:ADA
ALTERNATE NAMES:ADA, ADA1
ACCESSION NO.:NP_000013
PROTEIN GI NO.:47078295
GENE ID:100
USER NOTE:Optimal dilutions for each application to be determined by the researcher.

psi-iconBackground and References

BACKGROUND:ADA is an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia.This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine. Various mutations have been described for this gene and have been linked to human diseases. Deficiency in this enzyme causes a form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins, whereas elevated levels of this enzyme have been associated with congenital hemolytic anemia. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
REFERENCES:1) Cassani, B., (2008) Blood 111 (8), 4209-4219.

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