ACVR2A Recombinant Protein Cat. No.: 96-008

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Ala 20 - Pro 134
FUSION TAG:C-Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:40 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Activin receptor type IIA, ACTRIIA
ACCESSION NO.:NP_001607
OFFICIAL SYMBOL:ACVR2A
GENE ID:92
psi-iconBackground and References
BACKGROUND:Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein. ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well. Several type I I activin receptors have been identified and bind to different activins with different affinities.
REFERENCES:1) Donaldson CJ., et al., 1992, Biochem Biophys Res Commun 184 (1): 310–316.
2) Lewis KA., et al., 2000, Nature 404 (6776): 411–4.
3) De Winter JP., et al., 1996, Exp. Cell

FOR RESEARCH USE ONLY.

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