Activin Receptor IIB Antibody Cat. No.: 36-351

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psi-iconSpecifications

HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: Recombinant extracellular domain (ecd) of mouse activin receptor IIB.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: ELISA: (1:400) . Western Blot: (1:5000) . Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes the extracellular domain of human and mouse ACTR-IIB. Does not cross-react with related human proteins ActR-IIecd, BMPR-IIecd, BMPR-IAecd, BMPR-IBecd or ActR-Iecd.

psi-iconProperties

PURIFICATION:Antigen affinity purified.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.
CONCENTRATION:500 ug/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info

OFFICIAL SYMBOL:Acvr2b
ALTERNATE NAMES:ACVR2B; ACTR-IIB; Activin receptor type-2B
ACCESSION NO.:P27040
PROTEIN GI NO.:114727
GENE ID:11481
USER NOTE:Optimal dilutions for each application to be determined by the researcher.

psi-iconBackground and References

BACKGROUND:Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c). ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.

ANTIBODIES FOR RESEARCH USE ONLY.

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