Acetyl-TP53-K370 mAb Cat. No.: 13-883

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: A specific peptide of human Acetyl-TP53-K370
TESTED APPLICATIONS: IF, IP, WB
APPLICATIONS: WB: ,1:500 - 1:2000

IF: ,1:50 - 1:200

IP: ,1:20 - 1:50
POSITIVE CONTROL:1) HepG2 treated with Etoposide and Trichostatin
 2) Untreated
PREDICTED MOLECULAR WEIGHT: Observed: 53kDa

psi-iconProperties
PURIFICATION:Affinity purification
CLONALITY:Monoclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS:Store at -20˚C. Avoid freeze / thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:TP53 K370ac
ALTERNATE NAMES:TP53, P53, BCC7, LFS1, TRP53
GENE ID:7157
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

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