SARS-CoV-2 (COVID-19) Receptor ACE2 Reagents
ACE2 & Other Related Target ReagentsTo support the efforts of researchers worldwide in understanding and combating the COVID-19 virus (SARS-COV-2) and other coronaviruses, ProSci Incorporated provides validated cornavirus receptor ACE2 antibodies, as well as related targets. Check out our ACE2 Antibody (Cat. No. 3217) that was cited in Cell. |
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What is ACE2 receptor?
Angiotensin converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus COVID-19 (SARS-CoV-2, 2019-nCoV). Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role to both cross-species and human to human transmissions of SARS-CoV-2.[i].
SARS-CoV Antibodies
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ACE2 receptors interacts with the spike protein (S) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2 . The SARS-COV-2 spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting similar function. In a study on SARS-CoV, the virus infection occurred in well differentiated cilated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii] |
| ACE2 Product Highlights | |
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Our ACE2 Antibodies Reagents
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| 3215 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3217 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3227 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3229 | ELISA, IF, IHC-P, WB | Polyclonal | |
| ACE2 Antibody | 24-033 | WB, IHC | Polyclonal |
| ACE2 Antibody [3F1] | 10-604 | WB, IF, IHC | Monoclonal |
| 36-031 | ELISA, Flow, WB | Monoclonal | |
| 36-032 | ELISA, Flow, WB | Monoclonal | |
| 36-038 | ELISA, WB | Monoclonal | |
| 36-039 | ELISA, WB | Monoclonal |
SARS-CoV-2 (COVID-19) Receptor ACE2 Recombinant Protein
| Product | Cat. No. | Source | Fusion Tag | Sequence |
|---|---|---|---|---|
| Human ACE2 Recombinant Protein | 10-421 | Mammalian Cells | C-His Tag | Ser19 - Asp615 |
| Human ACE2 Recombinant Protein | 10-430 | E. Coli | N-His Tag | Leu392 - Ser740 |
| Human ACE2 Recombinant Protein | 10-432 | Mammalian Cells | Tag Free | Met1 - Ser740 |
| Human ACE2 Recombinant Protein | 10-114 | Human Cells | C-His-Avi Tag | Gln18 - Ser740 |
| Human ACE2 Recombinant Protein | 10-120 | Human Cells | C-Fc Tag | Gln18 - Ser740 |
| Biotinylated Human ACE2 Recombinant Protein | 10-202 | HEK293 Cells | His-Avi Tag | Gln18 - Ser740 |
| ACE2 Recombinant Protein | 92-724 | Human Cells | C-10 His Tag | Gln18 - Thr740 |
| Rhesus Macaque ACE2 Recombinant Protein | 92-725 | Human Cells | C-10 His Tag | Gln18 - Val739 |
| Rhesus Macaque ACE2 Recombinant Protein | 92-726 | Human Cells | C-Fc Tag | Gln18 - Val739 |
SARS-CoV-2 (COVID-19) Protease TMPRSS2 Antibody
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| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| 24-034 | IHC, WB | Monoclonal | |
| 46-908 | ELISA, WB | Polyclonal | |
| 18-426 | IHC, WB | Polyclonal | |
| 62-863 | Flow, WB | Polyclonal |
SARS-CoV-2 (COVID-19) Furin Antibody
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| 22-945 | IHC, WB | Polyclonal | |
| 14-925 | WB | Polyclonal | |
| 70-351 | IHC | Polyclonal | |
| 43-351 | ELISA, WB | Polyclonal |
SARS-CoV-2 (COVID-19) Furin Recombinant Protein
| Product | Cat. No. | Source | Fusion Tag | Sequence |
|---|---|---|---|---|
| Furin Recombinant Protein | 40-542 | HEK cells | His | Asp108-Glu715 |
| Furin Recombinant Protein | 96-331 | HEK cells | His | Asp108-Glu715 |
[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20
[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8
[iii] Jia HP, Look DC, Shi L, et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005;https://doi.org/10.1128/JVI.79.23.14614-14621.2005
