SARS-CoV-2 (COVID-19) Receptor ACE2 Reagents

SARS-CoV-2 (COVID-19) Receptor ACE2 antibodies and proteins at ProSci Inc.


ACE2 & Other Related Target Reagents

To support the efforts of researchers worldwide in understanding and combating the COVID-19 virus (SARS-COV-2) and other coronaviruses, ProSci Incorporated provides validated cornavirus receptor ACE2 antibodies, as well as related targets. Check out our ACE2 Antibody (Cat. No. 3217) that was cited in Cell.

ProSci SARS-CoV-2 Receptor ACE2 Independent Antibody Validation


What is ACE2 receptor?

Angiotensin converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus COVID-19 (SARS-CoV-2, 2019-nCoV). Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role to both cross-species and human to human transmissions of SARS-CoV-2.[i].

SARS-CoV Antibodies

ProSci ACE2 Receptor binding COVID-19

ACE2 receptors interacts with the spike protein (S) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2 . The SARS-COV-2  spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting similar function. In a study on SARS-CoV, the virus infection occurred in well differentiated cilated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii]     


ACE2 Product Highlights

Cat. No: 3215 ACE2 Antibody

SARS-CoV-2 (COVID-19) Recptor ACE2 Immunohistochemistry

Cat. No: 3217 ACE2 Antibody

SARS-CoV-2 (COVID-19) Recptor ACE2 Immunofluorescent Human Lung

Cat. No: 3227 ACE2 Antibody

SARS-CoV-2 (COVID-19) Recptor ACE2 Immunohistochemistry

Cat. No: 3229 ACE2 Antibody

SARS-CoV-2 (COVID-19) Recptor ACE2 Immunofluorescent Caco2 cells


Our ACE2 Antibodies Reagents

ProductCat. No.ApplicationClonality

ACE2 Antibody

3215 ELISA, IF, IHC-P, WB Polyclonal

ACE2 Antibody

3217 ELISA, IF, IHC-P, WB Polyclonal 

ACE2 Antibody

3227 ELISA, IF, IHC-P, WB Polyclonal 

ACE2 Antibody

3229 ELISA, IF, IHC-P, WB Polyclonal 
ACE2 Antibody 24-033 WB, IHC Polyclonal
ACE2 Antibody [3F1] 10-604 WB, IF, IHC Monoclonal

ACE2 Antibody[AC18F]

36-031 ELISA, Flow, WB Monoclonal 

ACE2 Antibody[AC18F](biotin)

36-032 ELISA, Flow, WB Monoclonal 

ACE2 Antibody[AC384]

36-038 ELISA, WB Monoclonal 

ACE2 Antibody[AC384](biotin)

36-039 ELISA, WB Monoclonal 



SARS-CoV-2 (COVID-19) Receptor ACE2 Recombinant Protein

ProductCat. No.SourceFusion TagSequence
Human ACE2 Recombinant Protein 10-421 Mammalian Cells C-His Tag Ser19 - Asp615
Human ACE2 Recombinant Protein 10-430 E. Coli N-His Tag Leu392 - Ser740
Human ACE2 Recombinant Protein 10-432 Mammalian Cells Tag Free Met1 - Ser740
Human ACE2 Recombinant Protein 10-114 Human Cells C-His-Avi Tag Gln18 - Ser740
Human ACE2 Recombinant Protein 10-120 Human Cells C-Fc Tag Gln18 - Ser740
Biotinylated Human ACE2 Recombinant Protein 10-202 HEK293 Cells His-Avi Tag Gln18 - Ser740
ACE2 Recombinant Protein 92-724 Human Cells C-10 His Tag Gln18 - Thr740
Rhesus Macaque ACE2 Recombinant Protein 92-725 Human Cells C-10 His Tag Gln18 - Val739
Rhesus Macaque ACE2 Recombinant Protein 92-726 Human Cells C-Fc Tag Gln18 - Val739


SARS-CoV-2 (COVID-19) Protease TMPRSS2 Antibody

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ProductCat. No.ApplicationClonality

TMPRRS2 Antibody

24-034 IHC, WB Monoclonal 

TMPRRS2 Antibody

46-908 ELISA, WB Polyclonal 

TMPRRS2 Antibody

18-426 IHC, WB Polyclonal 

TMPRRS2 Antibody

62-863 Flow, WB Polyclonal 


SARS-CoV-2 (COVID-19) Furin Antibody

ProductCat. No.ApplicationClonality

Furin Antibody

22-945 IHC, WB Polyclonal 

Furin Antibody

14-925 WB Polyclonal 

Furin Antibody

70-351 IHC Polyclonal 

Furin Antibody

43-351 ELISA, WB Polyclonal 


SARS-CoV-2 (COVID-19) Furin Recombinant Protein

ProductCat. No.SourceFusion TagSequence
Furin Recombinant Protein 40-542 HEK cells His Asp108-Glu715
Furin Recombinant Protein 96-331 HEK cells His Asp108-Glu715

 

References

[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20

[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8

[iii] Jia HP, Look DC, Shi L, et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005;https://doi.org/10.1128/JVI.79.23.14614-14621.2005