SARS-CoV-2 (COVID-19) Receptor ACE2 Reagents
ACE 2 & Other Related Target ReagentsTo support the efforts of researchers worldwide in understanding and combating COVID-19 virus SARS-COV-2 and other coronaviruses, ProSci provides validated cornavirus receptor ACE2 antibodies. As well as related targets. |
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| ACE 2 Product Highlights | |
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Our ACE2 Antibodies List
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| ACE2 Antibodies | Cat. No. | Application | Clonality |
|---|---|---|---|
| 3215 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3217 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3227 | ELISA, IF, IHC-P, WB | Polyclonal | |
| 3229 | ELISA, IF, IHC-P, WB | Polyclonal | |
| ACE2 Antibody | 24-033 | WB, IHC | Polyclonal |
| ACE2 Antibody | 10-531 | ELISA, WB | Polyclonal |
| ACE2 Antibody | 10-600 | WB, IHC-P, IF | Polyclonal |
| ACE2 Antibody | 10-601 | WB, IHC-P, IF | Polyclonal |
| ACE2 Antibody | 10-602 | WB, IHC-P, IF | Polyclonal |
| ACE2 Antibody | 10-603 | WB, IHC-P, IF | Polyclonal |
| ACE2 Antibody [3F1] | 10-604 | WB, IF, IHC | Monoclonal |
| 70-543 | ELISA, Flow, IHC, WB | Polyclonal | |
| 36-031 | ELISA, Flow, WB | Monoclonal | |
| 36-032 | ELISA, Flow, WB | Monoclonal | |
| 36-038 | ELISA, WB | Monoclonal | |
| 36-039 | ELISA, WB | Monoclonal |
COVID-19 (SARS-CoV-2) Virus Receptor ACE2 Recombinant Protein
| Product | Cat. No. | Source | Fusion Tag | Sequence |
|---|---|---|---|---|
| ACE-2 Recombinant Protein | 91-376 | Human Cells | C-6 His Tag | Gln18-Ser740 |
| ACE-2 Recombinant Protein | 10-014 | HEK293 cells | His Tag | Gln18-Ser740 |
| Human ACE2 Recombinant Protein | 10-114 | Human Cells | His, Avi tag at the C-terminus | Gln18- Ser740 |
| Human ACE2 Recombinant Protein | 10-120 | Human Cells | Fc tag at the C-terminus | Arg319-Phe541 |
| Human ACE2 Recombinant Protein | 10-200 | HEK293 cells | His-Avi Tag | Gln18- Ser740 |
COVID-19 (SARS-CoV-2) Virus Receptor ACE2 Protease TMPRSS2 Antibody
| Product | Cat. No. | Application | Clonality |
|---|---|---|---|
| 24-034 | IHC, WB | Monoclonal | |
| 46-908 | ELISA, WB | Polyclonal | |
| 18-426 | IHC, WB | Polyclonal | |
| 62-863 | Flow, WB | Polyclonal |
What is ACE2 receptor?
Angiotensin converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus SARS-CoV-2 (2019-nCoV). Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role to both cross-species and human to human transmissions of SARS-CoV-2.[i].
SARS-COV-2 and ACE2 receptor interaction
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ACE2 receptors interacts with the spike protein (s) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2 . The SARS-COV-2 spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting similar function. In a study on SARS-CoV, the virus infection occurred in well differentiated cilated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii] |
[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20
[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8
[iii] Jia HP, Look DC, Shi L, et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005;https://doi.org/10.1128/JVI.79.23.14614-14621.2005
