SARS-CoV-2 (COVID-19) Receptor ACE2 Reagents
Learn more about our COVID-19 Reagents and Antibody Services:
ACE2 & Other Related Target Reagents
To support the efforts of researchers worldwide in understanding and combating the COVID-19 virus (SARS-COV-2) and other coronaviruses, ProSci Incorporated provides validated cornavirus receptor ACE2 antibodies, as well as related targets. Check out our ACE2 Antibody (Cat. No. 3217) that was cited in Cell.
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What is ACE2 receptor?
Angiotensin converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus COVID-19 (SARS-CoV-2, 2019-nCoV). Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role to both cross-species and human to human transmissions of SARS-CoV-2.[i].
SARS-CoV Antibodies
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ACE2 receptors interacts with the spike protein (S) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2 . The SARS-COV-2 spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting similar function. In a study on SARS-CoV, the virus infection occurred in well differentiated cilated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii]
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Our ACE2 Antibodies Reagents
Product | Cat. No. | Application | Clonality |
ACE2 Antibody
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3215 |
ELISA, IF, IHC-P, WB |
Polyclonal |
ACE2 Antibody
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3217 |
ELISA, IF, IHC-P, WB |
Polyclonal |
ACE2 Antibody
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3227 |
ELISA, IF, IHC-P, WB |
Polyclonal |
ACE2 Antibody
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3229 |
ELISA, IF, IHC-P, WB |
Polyclonal |
ACE2 Antibody |
24-033 |
WB, IHC |
Polyclonal |
ACE2 Antibody [3F1] |
10-604 |
WB, IF, IHC |
Monoclonal |
ACE2 Antibody[AC18F]
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36-031 |
ELISA, Flow, WB |
Monoclonal |
ACE2 Antibody[AC18F](biotin)
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36-032 |
ELISA, Flow, WB |
Monoclonal |
ACE2 Antibody[AC384]
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36-038 |
ELISA, WB |
Monoclonal |
ACE2 Antibody[AC384](biotin)
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36-039 |
ELISA, WB |
Monoclonal |
SARS-CoV-2 (COVID-19) Receptor ACE2 Recombinant Protein
[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20
[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8