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ACE2 Antibodies

What is ACE2 receptor?

Angiotensin converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus SARS-CoV-2 (2019-nCoV). Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role to both cross-species and human to human transmissions of SARS-CoV-2.[i].

SARS-COV-2 and ACE2 receptor interaction

ProSci ACE2 Receptor binding COVID-19

ACE2 receptors interacts with the spike protein (s) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2 . The SARS-COV-2  spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting similar function. In a study on SARS-CoV, the virus infection occurred in well differentiated cilated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii]     

                         

ProSci ACE2 Reagents

To support the efforts of researchers worldwide in understanding and combating SARS-COV-2 and other coronaviruses, ProSci provides validated ACE2 receptor antibodies below.

ProSci SARS-CoV-2 Receptor ACE2 Independent Antibody Validation

ProductCat. No.HostApplicationReactivityBlocking Peptide
ACE2 Antibody 3215 Rabbit ELISA, IF, IHC-P, WB Human, Mouse, Rat Blocking Peptide
ACE2 Antibody 3217 Rabbit ELISA, IF, IHC-P, WB Human, Mouse, Rat Blocking Peptide
ACE2 Antibody 3227 Rabbit ELISA, IF, IHC-P, WB Human, Mouse, Rat Blocking Peptide
ACE2 Antibody 3229 Rabbit ELISA, IF, IHC-P, WB Human, Mouse, Rat Blocking Peptide

SARS-CoV-2 Products

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References

[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20

[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8

[iii] Jia HP, Look DC, Shi L, et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005;https://doi.org/10.1128/JVI.79.23.14614-14621.2005