ACE-2 Recombinant Protein Cat. No.: 10-014

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln18-Ser740
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA
APPLICATIONS:E, WB
BIOLOGICAL ACTIVITY: Human ACE2 protein can bind with SARS-CoV-2 Spike protein (RBD) in functional ELISA assay.
psi-iconProperties
PURITY:>95% as determined by reducing SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:Mol Mass: 84.63kD; AP Mol Mass: 103kD
PHYSICAL STATE:Liquid
BUFFER:20mM Tris, 300mM NaCl, 1mM ZnCl2, 10% Glycerol, pH 7.4.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store in working aliquots at -20˚C. Avoid freeze/thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Angiotensin-Converting Enzyme 2, ACE-Related Carboxypeptidase, Angiotensin-Converting Enzyme Homolog, ACEH, Metalloprotease MPROT15, ACE2
ACCESSION NO.:Q9BYF1
OFFICIAL SYMBOL:ACE2
GENE ID:59272
psi-iconBackground and References
BACKGROUND:Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family which includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase and converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be highly expressed in testis, kidney, heart, colon, small intestine and ovary at moderate levels. ACE2 is not inhibited by the classical ACE inhibitors, captopril and lisinopril and may play an important role in regulating the heart function.

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