ABL1 / 2 (phospho Tyr393 / Tyr429) Antibody Cat. No.: 79-245

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: ABL1/2 (phospho-Tyr393/429) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y (p) -T-A) derived from Human ABL1/2.
TESTED APPLICATIONS: IF, IHC, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/429.
PREDICTED MOLECULAR WEIGHT: 210 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:ABL1 ABL2
ALTERNATE NAMES:ABL, JTK7, p150, c-ABL, v-abl, c-ABL1, bcr/abl, BHLHE39, Abelson murine leukemia viral oncogene homolog 1
ACCESSION NO.:NP_005148.2 / NP_001129472.1
PROTEIN GI NO.:62362414 / 209862772
GENE ID:25 / 27
psi-iconBackground and References
BACKGROUND:Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
REFERENCES:1) Wang, J. Y. et al. (2000) Oncogene 19, 5643-5650. Danial, N. N. et al. (2000) Oncogene 19, 2523-2531. Brasher, B. B. et al. (2000) J. Biol. Chem. 275, 35631-35637. Pluk, H. et al. (2002) Cell 108, 247-259.

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