ABCG2 Antibody Cat. No.: 19-779

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Monkey, Mouse, Rat
IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 260-395 of human ABCG2 (NP_004818.2).
TESTED APPLICATIONS: IF, WB
APPLICATIONS: WB: ,1:500 - 1:2000

IF: ,1:50 - 1:100
POSITIVE CONTROL:1) COS-7
 2) A-549
 3) Mouse liver
 4) Mouse spleen
 5) Rat kidney
PREDICTED MOLECULAR WEIGHT: Observed: 72kDa

psi-iconProperties
PURIFICATION:Affinity purification
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS:Store at -20˚C. Avoid freeze / thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:ABCG2
ALTERNATE NAMES:ABCG2, ATP-binding cassette, sub-family G (WHITE), member 2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1, ABC transporter, ATP-binding cassette sub-family G member 2, ATP-binding cassette transporter G2, breast
GENE ID:9429
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.

ANTIBODIES FOR RESEARCH USE ONLY.

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