Datasheet

ABCB7 Antibody
CATALOG NUMBER: 62-131

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Mouse, Rat
TESTED APPLICATIONS:IHC-P, WB
APPLICATIONS:For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
PREDICTED MOLECULAR WEIGHT:83 kDa
IMMUNOGEN:This ABCB7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 718-746 amino acids from the C-terminal region of human ABCB7.
HOST SPECIES:Rabbit

Properties

PURIFICATION:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:2 mg/ml
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ATP-binding cassette sub-family B member 7, mitochondrial, ATP-binding cassette transporter 7, ABC transporter 7 protein, ABCB7, ABC7
ACCESSION NO.:O75027
OFFICIAL SYMBOL:ABCB7
GENE ID:22

Background

BACKGROUND:The membrane-associated protein ABCB7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
REFERENCES: 1) Allikmets, R., et al., Hum. Mol. Genet. 8(5):743-749 (1999).
2) Csere, P., et al., FEBS Lett. 441(2):266-270 (1998).
3) Mao, M., et al., Proc. Natl. Acad. Sci. U.S.A. 95(14):8175-8180 (1998).
4) Shimada, Y., et al., J. Hum. Genet. 43(2):115-122 (1998).

For Research Use Only