| SPECIES: | Human |
| SOURCE SPECIES: | E. coli |
| SEQUENCE: | Ile141-Val247 |
| FUSION TAG: | N-Trx tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant protein can be used for biological assays. For research use only. |
Specifications| PURITY: | Greater than 95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. |
| PREDICTED MOLECULAR WEIGHT: | 29.4 kD |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | Lyophilized from a 0.2 um filtered solution of 20mM PB，150mM NaCl,pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. |
| STORAGE CONDITIONS: | Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months. |
| ALTERNATE NAMES: | ATP-binding cassette sub-family B member 5, P-glycoprotein ABCB5, ABCB5 P-gp, ABCB5 |
| ACCESSION NO.: | Q2M3G0 |
| OFFICIAL SYMBOL: | ABCB5 |
| GENE ID: | 340273 |
| BACKGROUND: | ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments. |
FOR RESEARCH USE ONLY.
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