Datasheet

AASS Antibody
CATALOG NUMBER: 61-501

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:IHC-P, WB
APPLICATIONS:For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
PREDICTED MOLECULAR WEIGHT:102 kDa
IMMUNOGEN:This AASS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-294 amino acids from the Central region of human AASS.
HOST SPECIES:Rabbit

Properties

PURIFICATION:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:2 mg/ml
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, LKR, LOR, Saccharopine dehydrogenase, SDH, AASS
ACCESSION NO.:Q9UDR5
PROTEIN GI NO.:46396032
OFFICIAL SYMBOL:AASS
GENE ID:10157

Background

BACKGROUND:AASS is a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in the gene encoding this protein are associated with familial hyperlysinemia.
REFERENCES: 1) Sacksteder,K.A., Am. J. Hum. Genet. 66 (6), 1736-1743 (2000)

For Research Use Only