Datasheet

AASS Antibody
CATALOG NUMBER: 55-621

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:Flow, WB
APPLICATIONS:For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
PREDICTED MOLECULAR WEIGHT:102 kDa
IMMUNOGEN:This AASS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 805-834 amino acids from the C-terminal region of human AASS.
HOST SPECIES:Rabbit

Properties

PURIFICATION:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:2 mg/ml
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, LKR, LOR, Saccharopine dehydrogenase, SDH, AASS
ACCESSION NO.:Q9UDR5
PROTEIN GI NO.:46396032
OFFICIAL SYMBOL:AASS
GENE ID:10157

Background

BACKGROUND:This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively, resulting in the conversion of lysine to alpha-aminoadipic semialdehyde. Mutations in this gene are associated with familial hyperlysinemia.
REFERENCES: 1) Sacksteder, K.A., et al. Am. J. Hum. Genet. 66(6):1736-1743(2000)
2) Papes, F., et al. Biochem. J. 344 PT 2, 555-563 (1999) :

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