Datasheet

AANAT Antibody
CATALOG NUMBER: 64-035

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:WB
APPLICATIONS:For WB starting dilution is: 1:1000
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
PREDICTED MOLECULAR WEIGHT:23 kDa
IMMUNOGEN:This AANAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-54 amino acids from the N-terminal region of human AANAT.
HOST SPECIES:Rabbit

Properties

PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:0.32 mg/ml
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Serotonin N-acetyltransferase, Serotonin acetylase, Aralkylamine N-acetyltransferase, AA-NAT, AANAT, SNAT
ACCESSION NO.:Q16613
PROTEIN GI NO.:11387096
OFFICIAL SYMBOL:AANAT
GENE ID:15

Background

BACKGROUND:AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
REFERENCES: 1) Mansour, H.A., et al. Bipolar Disord 11(7):701-710(2009)
2) Gratacos, M., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 150B (6), 808-816 (2009)
3) Anderson, B.M., et al. Neurogenetics 10(3):209-216(2009)

For Research Use Only