Datasheet

AADAT Antibody
CATALOG NUMBER: 55-064

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:WB
APPLICATIONS:For WB starting dilution is: 1:1000
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
PREDICTED MOLECULAR WEIGHT:47 kDa
IMMUNOGEN:This AADAT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 196-224 amino acids from the Central region of human AADAT.
HOST SPECIES:Rabbit

Properties

PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, AadAT, Kynurenine aminotransferase II, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, AADAT, KAT2
ACCESSION NO.:Q8N5Z0
PROTEIN GI NO.:46395904
OFFICIAL SYMBOL:AADAT
GENE ID:51166

Background

BACKGROUND:This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.
REFERENCES: 1) Han, Q., et al. Biosci. Rep. 28(4):205-215(2008)
2) Rossi, F., et al. J. Biol. Chem. 283(6):3559-3566(2008)
3) Han, Q., et al. J. Biol. Chem. 283(6):3567-3573(2008)
4) Lamesch, P., et al. Genomics 89(3):307-315(2007)

For Research Use Only