a Synuclein (phospho Tyr136) Antibody Cat. No.: 79-491

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: a-Synuclein (Phospho-Tyr136) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 136 (Q-D-Y (p) -E-P) derived from Human α-Synuclein.
TESTED APPLICATIONS: IF, WB
APPLICATIONS: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
SPECIFICITY: This antibody detects endogenous level ofα-Synuclein only when phosphorylated at tyrosine 136.
PREDICTED MOLECULAR WEIGHT: 18 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:SNCA
ALTERNATE NAMES:PD1, NACP, PARK1, PARK4, FAK, FAK1, SYN, SYUA
ACCESSION NO.:NP_000336.1
PROTEIN GI NO.:4507109
GENE ID:6622
psi-iconBackground and References
BACKGROUND:May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
REFERENCES:1) Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

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