Datasheet

a Synuclein (phospho Ser129) Antibody
CATALOG NUMBER: 79-461

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:WB
APPLICATIONS:Western Blot: 1:500~1:1000
PREDICTED MOLECULAR WEIGHT:18 kDa
SPECIFICITY:This antibody detects endogenous level of VEGFR2 only when phosphorylated at tyrosine 1214.
IMMUNOGEN:a-Synuclein (Phospho-Ser129) antibody was raised against a peptide sequence around phosphorylation site of serine 129 (M-P-S (p) -E-E) derived from Human α-Synuclein.
HOST SPECIES:Rabbit

Properties

PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:PD1, NACP, PARK1, PARK4, ERBB, ERBB1, HER1, SYN, SYUA
ACCESSION NO.:NP_000336.1
PROTEIN GI NO.:4507109
OFFICIAL SYMBOL:SNCA
GENE ID:6622

Background

BACKGROUND:May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
REFERENCES: 1) Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

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